Parathyroid Hormone-related Protein Antagonizes the Action of Parathyroid Hormone on Adult Cardiomyocytes
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چکیده
منابع مشابه
Expression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells.
Thymic epithelial cells are an important source of cytokines and other regulatory peptides which guide thymocyte proliferation and maturation. Parathyroid hormone-related protein (PTHrP), a cytokine-like peptide, has been reported to affect the proliferation of lymphocytes in vitro. The studies presented here were undertaken to test the hypotheses that PTHrP is produced locally within the thymu...
متن کاملUnderstanding parathyroid hormone action.
In addition to regulating serum calcium and stimulating bone resorption, parathyroid hormone (PTH) is known to stimulate bone formation under certain conditions. The mechanisms behind this counterintuitive anabolic action are largely unknown. We have set out to identify PTH-regulated genes that might be responsible for each of these contrasting effects of the hormone. This article describes our...
متن کاملThe Bipartite Action of Parathyroid Hormone-related Peptide on Cartilage
軟骨の研究は,骨 代謝研究のなかでも発生生物学的な アプロー チの視点から急速に進歩 してきた領域の1つ で ある。軟骨細胞の分化増殖,さ らに軟骨内骨化に対する 調節因子の研究は,基 礎的な細胞生物学ばか りでなく先 天異常を含めた遺伝子疾患の解明にも及び,そ の必要性 が再認識 されている(図1)。 そのなかで副甲状腺ホルモ ン関連ペ プチ ド(parathyroid hormone-related peptide: PTHrP)は,軟 骨の分化増殖に最 も重要な因子で あり,多 くの研究者によってその詳細が明 らかにされて いる。PTHrPに ついては,す でに1950年 代 にAlbright が,悪 性腫瘍から産生される副甲状腺ホルモン(PTH) 様の物質でありhumoral hypercalcemia of malignancy の高カルシウム血症の起因物質 としてその存...
متن کاملChapter 26. Parathyroid Hormone-Related Protein
19. Brown EM, MacLeod RJ 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239-297. 20. Chang W, Chen TH, Pratt S, Shoback D 2000 Amino acids in the second and third intracellular loops of the parathyroid Ca2+sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem 27519955-19963. 21. Pearce SH, Williamson C, Kifor 0, Bai M, Coulthard MG, ...
متن کاملParathyroid hormone-related protein in teleost fish.
A brief description is given of the discovery of PTHrP and the roles of the peptide in mammalian physiology. Next, the occurrence of PTHrP in the earliest vertebrates, sharks, skates and fishes, is reviewed and the calciotropic functions of PTHrP are addressed more specifically in fishes. Parathyroid hormone-related protein (PTHrP) is a hypercalcemic hormone in teleostean fishes, but also has p...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.6.3074